The following has evaluated to null or missing:
==> .vars['reserved-article-group-id'] [in template "161555#161602#ARTICLE-PAGE---HERO" at line 14, column 20]
----
Tip: It's the final [] step that caused this error, not those before it.
----
Tip: If the failing expression is known to legally refer to something that's sometimes null or missing, either specify a default value like myOptionalVar!myDefault, or use <#if myOptionalVar??>when-present<#else>when-missing</#if>. (These only cover the last step of the expression; to cover the whole expression, use parenthesis: (myOptionalVar.foo)!myDefault, (myOptionalVar.foo)??
----
----
FTL stack trace ("~" means nesting-related):
- Failed at: #assign groupId = .vars["reserved-art... [in template "161555#161602#ARTICLE-PAGE---HERO" at line 14, column 1]
----
1<#assign namespace = randomNamespace />
2<#assign JSONFactoryUtil = staticUtil["com.liferay.portal.kernel.json.JSONFactoryUtil"] />
3<#assign journalArticleLocalService = serviceLocator.findService("com.liferay.journal.service.JournalArticleLocalService") />
4<#assign containerId = randomNamespace />
5<#assign shareURL = themeDisplay.getPortalURL()+themeDisplay.getURLCurrent()/>
6
7<#-- Auto-assign ALL category to every article -->
8<#assign assetCategoryLocalService = serviceLocator.findService("com.liferay.asset.kernel.service.AssetCategoryLocalService") />
9<#assign assetEntryLocalService = serviceLocator.findService("com.liferay.asset.kernel.service.AssetEntryLocalService") />
10<#assign journalArticleLocalService = serviceLocator.findService("com.liferay.journal.service.JournalArticleLocalService") />
11
12<#-- Get current JournalArticle -->
13<#assign articleId = .vars['reserved-article-id'].data />
14<#assign groupId = .vars['reserved-article-group-id'].data?number />
15<#assign journalArticle = journalArticleLocalService.getArticle(groupId, articleId) />
16
17<#-- Get AssetEntry for this article -->
18<#assign assetEntry = assetEntryLocalService.getEntry("com.liferay.journal.model.JournalArticle", journalArticle.getResourcePrimKey()) />
19
20<#-- Your ALL category ID -->
21<#assign allCategoryId = 4614994 />
22
23<#-- Assign ALL category if not already set -->
24<#if !assetEntry.getCategories()?seq_contains(assetCategoryLocalService.getCategory(allCategoryId))>
25 <#assign categoryIds = assetEntry.getCategoryIds() + [allCategoryId] />
26 ${assetEntryLocalService.updateEntry(
27 assetEntry.getUserId(),
28 assetEntry.getGroupId(),
29 assetEntry.getClassName(),
30 assetEntry.getClassPK(),
31 assetEntry.getUuid(),
32 assetEntry.getClassTypeId(),
33 categoryIds,
34 assetEntry.getTagNames()
35 )}
36</#if>
37
38<div class="hero jmarticle__hero-main-container">
39 <div class="container">
40 <div class="row">
41 <div class="article__cont">
42 <h1 class="article__heading">${Title.getData()}</h1>
43 <#if (SubTitle.getData())??>
44 <p class="article__para">
45 ${SubTitle.getData()}
46 </p>
47 </#if>
48
49 <#assign Date_Data=getterUtil.getString(Date.getData())>
50 <#if validator.isNotNull(Date_Data)>
51 <p class="article__date">
52 <#assign Date_DateObj=dateUtil.parseDate("yyyy-MM-dd", Date_Data, locale)>
53 ${dateUtil.getDate(Date_DateObj, "dd MMMM yyyy", locale)}
54 </p>
55 </#if>
56
57 <#if Link_Title?? && Link_Title.getData()?has_content>
58 <#list Link_Title.getSiblings() as cur_Link_Title>
59 <#if cur_Link_Title?? && cur_Link_Title.getData()?has_content>
60 <#assign linkHref="#" />
61 <#assign target="" />
62
63 <#assign rowId = containerId + cur_Link_Title?index />
64 <#if cur_Link_Title.Link_Internal?? && cur_Link_Title.Link_Internal.getFriendlyUrl()?has_content>
65 <#assign linkHref=cur_Link_Title.Link_Internal.getFriendlyUrl() />
66 <#elseif cur_Link_Title.Link_Media?? && cur_Link_Title.Link_Media.getData()?has_content>
67 <#assign linkHref=cur_Link_Title.Link_Media.getData() />
68 <#elseif cur_Link_Title.Link_Mailto?? && cur_Link_Title.Link_Mailto.getData()?has_content>
69 <#assign linkHref="mailto:" + cur_Link_Title.Link_Mailto.getData() />
70 <#elseif cur_Link_Title.Link_External?? && cur_Link_Title.Link_External.getData()?has_content>
71 <#assign linkHref=cur_Link_Title.Link_External.getData() />
72 </#if>
73 <#if (cur_Link_Title.Link_Target??) && (cur_Link_Title.Link_Target.getData())?has_content>
74 <#assign target=cur_Link_Title.Link_Target.getData() />
75 </#if>
76 <div id="blue_button_click_div" data-analytics-asset-type="custom">
77 <div class="jmarticle__hero-btn-list">
78 <a id="panel_blue_button_${rowId}" class="article__btn" href="${linkHref}" title="${cur_Link_Title.getData()}" target="${target}" data-analytics-asset-action="click" onclick="onBlueButtonClick(this)" >
79 <span class="btn__text">${cur_Link_Title.getData()}</span>
80 <span class="arrow__forward"></span>
81 </a>
82 </div>
83 </div>
84 </#if>
85 </#list>
86 </#if>
87 <div class="article-download-share">
88
89 <#if PDFTitle?? && PDFTitle.getData()?has_content>
90 <#assign title = PDFTitle.getData() />
91 <#assign pdf_link = "#" />
92 <#assign pdfrowId = containerId />
93 <#if PDFTitle.PDF?? && PDFTitle.PDF.getData()?has_content>
94 <#assign pdf_link = PDFTitle.PDF.getData() />
95 </#if>
96 <div class="article-download">
97 <div id="blue_button_click_div" data-analytics-asset-type="custom">
98 <div class="jmarticle__hero-btn-list">
99 <a id="panel_blue_button_${pdfrowId}" class="article__btn" href="${pdf_link}" title="${title}" data-analytics-asset-action="click" onclick="onBlueButtonClick(this)">
100 <span class="btn__text">${title}</span>
101 <span class="arrow__forward"></span>
102 </a>
103 <a id="panel_blue_button_${pdfrowId}" class="article__btn-mobile" href="${pdf_link}" title="${title}" data-analytics-asset-action="click" onclick="onBlueButtonClick(this)">
104 <img src="${themeDisplay.getPathThemeImages()}/new__jm__images/download-white-icon.svg" alt="twitter image"/>
105 </a>
106 </div>
107 </div>
108 </div>
109 </#if>
110
111 </div>
112
113 </div>
114 </div>
115 <#if (ImageLarge.getData())?? && ImageLarge.getData() != "">
116 <div class="row jmarticle__hero-banner" id="jmarticle__hero-${namespace}"
117 style="background-image: url(${ImageLarge.getData()})">
118 </#if>
119
120 </div>
121 </div>
122</div>
123
124<#if Author?? && Author.getData()?has_content>
125 <div class="jmarticle__author-info">
126 <div class="container">
127 <div class="hero__bar">
128 <#list Author.getSiblings() as cur_Author>
129 <#if cur_Author?? && cur_Author.getData()?has_content>
130 <#assign
131 webContentData = jsonFactoryUtil.createJSONObject(cur_Author.getData())
132 gId = groupId
133 journalArticle = journalArticleLocalService.getArticleByUrlTitle(gId, webContentData.title)
134 docXML = saxReaderUtil.read(journalArticle.getContent())
135
136 fName = docXML.valueOf("//dynamic-element[@name='FullName']/dynamic-content/text()")
137 jobTitle = docXML.valueOf("//dynamic-element[@name='JobTitle']/dynamic-content/text()")
138 role = docXML.valueOf("//dynamic-element[@name='ContactInfo']/dynamic-content/text()")
139 photoXML = docXML.valueOf("//dynamic-element[@name='Photo']/dynamic-content/text()")
140 photoSrc = JSONFactoryUtil.createJSONObject(photoXML).getString("uuid")
141 fullName = docXML.valueOf("//dynamic-element[@name='Title']/dynamic-content/text()")
142 authorImageXML = docXML.valueOf("//dynamic-element[@name='ImageLarge']/dynamic-content/text()")
143 authImageSrc = JSONFactoryUtil.createJSONObject(authorImageXML).getString("uuid")
144 summary = docXML.valueOf("//dynamic-element[@name='Summary']/dynamic-content/text()")
145 />
146
147 <div class="author">
148 <figure class="author__image">
149 <#if authImageSrc?? && authImageSrc?has_content>
150 <img src="/documents/${groupId}/${authImageSrc}" alt="${fullName}" class="author_img_class_new">
151 <#elseif photoSrc?? && photoSrc?has_content>
152 <img src="/documents/${groupId}/${photoSrc}" alt="${fName}" class="author_img_class_new">
153 </#if>
154 </figure>
155 <div class="author__details d-flex flex-column">
156 <h3 class="author__name">
157 <a rel="author">
158 <#if fullName?? && fullName?has_content>
159 ${fullName}
160 <#elseif fName?? && fName?has_content>
161 ${fName}
162 </#if>
163 </a>
164 </h3>
165 <p class="author__desc text-size-a author_job_title">
166 <#if jobTitle?? && jobTitle?has_content>
167 ${jobTitle}
168 </#if>
169 </p>
170 <span>
171 <p class="author__desc text-size-a">
172 <#if summary?? && summary?has_content>
173 ${summary}
174 </#if>
175 <#if role?? && role?has_content>
176 ${role}
177 </#if>
178 </p>
179 </span>
180 </div>
181 <div>
182 <div class="author__contact">
183 <ul class="author__contact-list">
184 </ul>
185 </div>
186 </div>
187 </div>
188 </#if>
189 </#list>
190 </div>
191 </div>
192 </div>
193</#if>
194
195
196
197<div class="container">
198 <div class="row">
199 <div class="article__intro">
200 <#if (Introduction.getData())??>
201 ${Introduction.getData()}
202 </#if>
203
204 <div class="article-download-share">
205
206 <#if PDFTitle?? && PDFTitle.getData()?has_content>
207 <#assign title = PDFTitle.getData() />
208 <#assign pdf_link = "#" />
209 <#assign pdfrowId = containerId />
210 <#if PDFTitle.PDF?? && PDFTitle.PDF.getData()?has_content>
211 <#assign pdf_link = PDFTitle.PDF.getData() />
212 </#if>
213 <div class="article-download">
214 <div id="blue_button_click_div" data-analytics-asset-type="custom">
215 <div class="jmarticle__hero-btn-list">
216 <a id="panel_blue_button_${pdfrowId}" class="article__btn" href="${pdf_link}" title="${title}" data-analytics-asset-action="click" onclick="onBlueButtonClick(this)">
217 <span class="btn__text">${title}</span>
218 <span class="arrow__forward"></span>
219 </a>
220 <a id="panel_blue_button_${pdfrowId}" class="article__btn-mobile" href="${pdf_link}" title="${title}" data-analytics-asset-action="click" onclick="onBlueButtonClick(this)">
221 <img src="${themeDisplay.getPathThemeImages()}/new__jm__images/download-white-icon.svg" alt="twitter image"/>
222 </a>
223 </div>
224 </div>
225 </div>
226 </#if>
227
228
229 <div class="article-share">
230 <a href="https://linkedin.com/shareArticle?url=${shareURL}&title=<#if (Title.getData())??>${Title.getData()}</#if>" target="_blank">
231 <img class="socialicons__img" src="${themeDisplay.getPathThemeImages()}/new__jm__images/social_icons-LinkedIN.png" alt="twitter image"/>
232 </a>
233 <a href="https://twitter.com/share?url=${shareURL}&text=<#if (Title.getData())??>${Title.getData()}</#if>" target="_blank">
234 <img class="socialicons__img" src="${themeDisplay.getPathThemeImages()}/new__jm__images/social_icons-Twitter.png" alt="twitter image"/>
235 </a>
236 </div>
237 </div>
238
239 </div>
240 </div>
241</div>
242
243<style>
244 img.author_img_class_new {
245 width: 100% !important;
246 height: 100% !important;
247 position: absolute;
248 margin: auto;
249 top: 0;
250 bottom: 0;
251 }
252
253 .article__btn:focus-visible {
254 outline: 2px solid blue !important;
255}
256
257@media (min-width: 320px) and (max-width: 650px) {
258 .article__intro li {
259 margin-left: -32px !important;
260 }
261 .journal-content-article .container .article__intro {
262 margin-top: 22px !important;
263}
264}
265@media (min-width: 540px) and (max-width: 834px) {
266 .article__intro li {
267 margin-left: -32px !important;
268 }
269 .article__intro {
270 margin: 60px 15px 0 5px !important;
271 }
272}
273
274@media (min-width: 320px) and (max-width: 539px){
275.jmarticle__author-info {
276 padding: 0px 0;
277}
278.jmarticle__author-info .author__image {
279 width: 39px;
280 height: 40px;
281}
282
283.jmarticle__author-info .author__name a {
284 line-height: 0px;
285 font-size: 18px !important;
286 margin-right: 10px;
287}
288
289.jmarticle__author-info .author__desc {
290
291 line-height: 14px;
292 font-size: 12px !important;
293 margin-bottom: 7px;
294}
295}
296
297</style>
Active pharmaceutical ingredients (APIs) are inherently complex, and synthesis can require multiple, diverse reaction steps. Strict regulation surrounds API development, such as restricting levels of impurities - making product isolation and purification high priorities. This leads to lengthy or multi-step manufacturing processes and loss of efficiency. In practice, the process of streamlining drug development is challenging. But processes can be accelerated by applying technological innovation from early concept to optimising formulation.
Advanced catalytic activity
The first task in any drug development process is the API synthesis. APIs are complex structures, typically containing multiple chiral centres, and synthesis requires many precise stereoselective reactions. The tasks of finding the shortest, most efficient reaction pathway requires chemical innovation and creativity. And this is where our strength in catalysis plays an important role.
Many pharmaceutical compounds contain chiral centres. Cipralex (left) is an antidepressant and Levofloxacin (right) is an antibiotic defined by the WHO as an essential medicine.
In chemistry, many different reactions can lead to the same structure. This presents various opportunities to implement catalysis into any API development process. Specific catalysts are stereoselective and are often able to react at selected reaction sites, reducing the prospect of unwanted side reactions. Careful catalyst choice could reduce multiple reaction steps to a single, stereoselective step, avoiding the need for separation. We use modelling and knowledge of reaction mechanisms to determine the right reactions for the most effective production of the API.
Experimental catalysis screening can be used to optimise the production process, commonly involving specific catalyst kits. By choosing the right process, involving the most up-to-date, innovative chemistry to synthese the right molecule, unnecessary delays can be prevented.
Combining technologies with collaborations
It can be challenging to scale up processes that work on a laboratory scale but these can be overcome through collaborations and the sharing of scientific expertise. We work closely with our customers to make sure the reaction process and catalysts are right for them.
For example, continuous flow reactions can improve API manufacture. One recent process development we worked on through a collaborative development agreement with Snapdragon Chemistry Inc involved the integration of continuous reaction pathways into API synthesis.
Continuous reaction processes work by applying a constant flow of raw reagents while simultaneously removing products. The advantage of these methodologies is, little production downtime and shortening the API production process. In fact, it is possible that a month-long batch process could be shortened to just a single day using continuous manufacture technology and continually removing the API product reduces the opportunities for unwanted side-reactions to occur, whilst continuous product purification and isolation can also be integrated, further accelerating the synthetic process.
Selecting the appropriate solid form
Following API synthesis, the next task is addressing how the drug is administered. Molecules can have different solid forms, a term that incorporates a molecule’s potential crystalline and amorphous structures. Most drugs are crystalline, and combinations of the API with various guests – such as solvent or other salt crystals - can exist in multiple orientations.
Even aspirin comes in a range of polymorphs, which must be controlled for the final tablet.
We have expertise in developing optimal polymorphs, salt forms, crystal morphology and controlled particles through our knowhow in solid form sciences. We offer one of the broadest and most reliable services to ensure effective identification, development and manufacture of your drug candidates and commercial products.
Understanding the molecular solid form enables physiochemical properties such as solubility, stability and bioavailability to be investigated. Due to the wide variety of possible formulation combinations, the appropriate form will depend on the method of drug administration. Properties of oral formulations will need to be fundamentally different to an intravenous formulation.
API’s solid form can be manipulated to fine-tune the desired physiochemical properties. To achieve this, two properties of the API are commonly changed in the development process: co-crystallisation and selecting an appropriate salt form. However, solid form manipulation must be performed on a case-by-case basis. What works for one oral formulation is not always guaranteed to work for other formulations.
Developing a different co-crystal of the API will alter the solid form due to the involvement of different intermolecular interactions. Co-crystal screening is needed owing to the inherent unpredictability entailed by different combinations of co-crystals.
Most drugs available on the market exist as salts which necessitate synthesis with an appropriate counter-ion. Changing this counter-ion allows for the optimisation of the physiochemical properties needed for the specific formulation. We can screen various counter-ions can optimise this process.
Different solid forms must be frequently characterised throughout the development process to determine whether the formulation conforms to the desired physical or chemical properties. Characterisation methods typically employed include: x-ray powder diffraction, which identifies the crystalline form of the drug; infra-red, nuclear magnetic resonance and Raman spectroscopic techniques, which are used to measure intermolecular interactions; and finally, other methods can measure properties including melting points, phase transformations and solubility.
Looking to the future
Reducing the number of synthetic stages, rapidly identifying the relevant physical forms of the product and making it stable in a bioavailable, formulated form all help to accelerate the time to develop and deliver the drug to the patient. It is fundamental to ensure product quality is held to the highest standard and is focused on delivering effective, timely patient care.
Article originally published on Chemistry World on March 13th 2018.
